Nuclear lamins and chromatin: When structure meets function
نویسندگان
چکیده
منابع مشابه
When Lamins Go Bad: Nuclear Structure and Disease
Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a group of phenotypically diverse genetic disorders known as laminopathies, which have symptoms that range from muscular dystrophy to neuropathy to premature aging syndromes. Although precise disease mechanisms remain unclear, there has been substantial progress in our understanding of not only laminopat...
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Recent work in plants and other eukaryotes has uncovered a major role for RNA interference in silent chromatin formation. The heritability of the silent state through multiple cell division cycles and, in some instances, through meiosis is assured by epigenetic marks. In plants, transposable elements and transgenes provide striking examples of the stable inheritance of repressed states, and are...
متن کاملNuclear lamins: key regulators of nuclear structure and activities
The nuclear lamina is a proteinaceous structure located underneath the inner nuclear membrane (INM), where it associates with the peripheral chromatin. It contains lamins and lamin-associated proteins, including many integral proteins of the INM, chromatin modifying proteins, transcriptional repressors and structural proteins. A fraction of lamins is also present in the nucleoplasm, where it fo...
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ژورنال
عنوان ژورنال: Advances in Enzyme Regulation
سال: 2009
ISSN: 0065-2571
DOI: 10.1016/j.advenzreg.2008.12.003